In the absence of a WNT signal, the cytoplasmic destruction complex (APC, Axin, GSK3β, CK1) is active. This complex phosphorylates β-Catenin, tagging it for recognition by a ubiquitin ligase. The ubiquitinated β-Catenin is then rapidly degraded by the proteasome, preventing it from accumulating and entering the nucleus.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies