Air Pollutants as Toxic Agents
Q: True or False: The pH of normal rainwater is neutral (pH 7.0).
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In the absence of a WNT signal, the cytoplasmic destruction complex (APC, Axin, GSK3β, CK1) is active. This complex phosphorylates β-Catenin, tagging it for recognition by a ubiquitin ligase. The ubiquitinated β-Catenin is then rapidly degraded by the proteasome, preventing it from accumulating and entering the nucleus.
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