Dermal Toxicology

Dermal Toxicology focuses on the skin as a major route of exposure and a target organ for chemical toxicity. This topic covers skin structure and function, factors affecting percutaneous absorption, and the biotransformation of xenobiotics in the skin. Zambian college and university students in biomedical science, occupational health, and dermatology will explore various dermal effects, including primary irritation, allergic contact dermatitis, photosensitization, chloracne, alopecia, and skin cancer. Understanding the mechanisms of action of agents like corrosive chemicals, allergens, phototoxic plants, and halogenated aromatics (e.g., dioxins) is crucial. This knowledge is key for examination success and for professional practice in diagnosing and managing occupational skin diseases, conducting risk assessments, and promoting dermal safety in Zambia's workplaces and communities.