mTORC1 (mechanistic Target of Rapamycin Complex 1) is the key anabolic driver downstream of PI3K/AKT. When activated (via Rheb-GTP), it phosphorylates substrates like S6K1 and 4E-BP1, which directly stimulate mRNA translation, ribosome biogenesis, and nutrient uptake, leading to increased protein synthesis and cell growth—processes essential for tumor progression.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies