DNA Proofreading and Repair

This topic examines the cellular mechanisms that correct DNA replication errors and repair DNA damage, including proofreading, mismatch repair, nucleotide excision repair, base excision repair, and double-strand break repair. Tailored for Zambian tertiary learners in genetics, pathology, or molecular biology programs, the module highlights how these processes prevent mutations and maintain genomic integrity. Students will explore the clinical relevance of repair pathway defects, such as in xeroderma pigmentosum and Lynch syndrome, and their association with cancer and genetic disorders. Mastery of DNA repair concepts is vital for passing university-level exams and for pursuing careers in clinical diagnostics, genetic counseling, or biomedical research within Zambia. The content aligns with degree and advanced diploma syllabi, emphasizing the link between molecular mechanisms and human disease, thereby equipping students with the knowledge to contribute to improved healthcare outcomes and scientific advancements.