Non-Mendelian Inheritance Patterns
Q: What is the term for the interaction of multiple genes to control a single trait?
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Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human Herpesvirus 8 (HHV-8), is a gammaherpesvirus. In addition to causing Kaposi's sarcoma, it is the etiological agent of two rare lymphoproliferative disorders: Primary Effusion Lymphoma (PEL), a body cavity-based B-cell lymphoma, and a plasma cell variant of Multicentric Castleman's Disease (MCD). In MCD, KSHV-infected B-cells produce viral IL-6 (v-IL-6), which drives systemic inflammatory symptoms.
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